| The Chicago Community Trust | Chicago | $25,940 | 7,053 | $5.8B |
| Iff | Chicago | $47,300 | 768 | $105.6M |
| National Council of Ymcas of the USA | Chicago | $43,078 | 687 | $150.5M |
| United Way of Metropolitan Chicago Inc | Chicago | $25,271 | 649 | $126.7M |
| The Rotary Foundation of Rotary | Evanston | $38,752 | 619 | $81.1M |
| Northwestern University | Evanston | $75,000 | 566 | $426.6M |
| Greater Chicago Food Depository | Chicago | $56,708 | 552 | $695.9M |
| Robert R Mccormick Foundation | Chicago | $50,750 | 483 | $314.8M |
| Northwestern Memorial Healthcare Group | Chicago | $25,000 | 330 | $109.8M |
| Muscular Dystrophy Association | Chicago | $36,705 | 272 | $51.7M |
| Forefront | Chicago | $50,000 | 236 | $28.9M |
| Action for Healthy Kids | Chicago | $33,226 | 191 | $9.2M |
| American Medical Association | Chicago | $30,000 | 186 | $30.2M |
| Eastern Illinois Foodbank | Urbana | $45,788 | 129 | $58.7M |
| Illinois Public Health Institute | Chicago | $25,000 | 103 | $3.3M |
| Coregiving Co | Chicago | $35,062 | 101 | $12.4M |
| P33 | Chicago | $25,000 | 95 | $2.9M |
| Loyola University of Chicago | Chicago | $32,574 | 91 | $13.6M |
| People's Action Institute | Chicago | $88,750 | 91 | $24.0M |
| Chicago Cubs Charities | Chicago | $25,000 | 88 | $8.3M |
| Big Shoulders Fund | Chicago | $86,854 | 88 | $47.8M |
| Omega Medical Grants Association | Rosemont | $27,500 | 84 | $7.8M |
| American Dental Association | Chicago | $56,000 | 84 | $32.7M |
| Underwriters Laboratories Inc | Evanston | $30,000 | 84 | $7.7B |
| Endeavor Health Clinical Operations | Arlington Heights | $86,404 | 84 | $338.2M |
| United Way of Champaign County | Savoy | $29,802 | 83 | $8.8M |
| American Epilepsy Society | Chicago | $39,250 | 82 | $5.5M |
| Rehabilitation Institute of Chicago | Chicago | $37,076 | 81 | $23.7M |
| Heart of Illinois United Way Inc | Peoria | $78,655 | 78 | $25.6M |
| American Property Casualty Insurance Association | Chicago | $25,000 | 76 | $10.3M |
| Jewish United Fund | Chicago | $36,000 | 73 | $376.9M |
| American Academy of Sleep Medicine | Darien | $83,786 | 71 | $12.3M |
| Aisc Holdings Inc | Chicago | $31,000 | 70 | $7.8M |
| Easter Seals Inc | Chicago | $57,118 | 69 | $92.7M |
| Elevate Energy | Chicago | $48,532 | 68 | $13.6M |
| Society of Actuaries Research Institute | Chicago | $25,000 | 67 | $6.1M |
| Illinois Agricultural Association | Bloomington | $43,446 | 66 | $11.8M |
| Memorial Health System Group | Springfield | $50,000 | 64 | $51.1M |
| Depaul University | Chicago | $28,084 | 60 | $8.3M |
| Global Philanthropy Partnership | Chicago | $47,500 | 59 | $2.8M |
| American Association of Nurse | Rosemont | $68,020 | 58 | $19.8M |
| The Chicago Bar Foundation | Chicago | $33,250 | 58 | $33.2M |
| Illinois Equal Justice Foundation | Chicago | $63,830 | 57 | $35.2M |
| Lawyers Trust Fund of Illinois | Chicago | $84,193 | 56 | $59.2M |
| Pillars Fund | Chicago | $50,000 | 56 | $7.6M |
| The Network Advocating Against Domestic | Chicago | $30,000 | 54 | $2.9M |
| Bears Care | Lake Forest | $30,000 | 50 | $10.1M |
| Igrb Foundation | Chicago | $50,000 | 50 | $6.6M |
| Ulta Beauty Charitable Foundation | Bolingbrook | $95,000 | 46 | $45.8M |
| Neurosurgery Research and Education | Rolling Meadows | $60,000 | 46 | $7.1M |
| Alliancechicago | Chicago | $25,327 | 46 | $5.8M |
| Center for Orthopaedic Trauma | Rosemont | $25,000 | 44 | $2.6M |
| National Partnership for New Americans | Chicago | $35,000 | 44 | $3.8M |
| American Hospital Association | Chicago | $25,250 | 43 | $17.4M |
| Cristo Rey Network | Chicago | $78,000 | 42 | $20.3M |
| Mount Zion Baptist World Missions | Fairfield | $28,850 | 42 | $4.2M |
| Partnership for Cures | Chicago | $40,000 | 41 | $2.6M |
| Saem Research Foundation | Des Plaines | $25,000 | 41 | $3.5M |
| Heartland Alliance for Human Needs and Rights | Chicago | $52,720 | 38 | $23.2M |
| Acclivus Inc | Chicago | $90,731 | 37 | $6.8M |
| Masonic Family Health Services | Chicago | $25,000 | 36 | $7.3M |
| World Business Chicago | Chicago | $25,000 | 36 | $2.2M |
| The Barack Obama Foundation | Chicago | $50,000 | 36 | $28.3M |
| Shure Charitable Trust Created Uw of | Chicago | $25,000 | 33 | $9.9M |
| Impact Grants Chicago | Chicago | $48,771 | 33 | $2.0M |
| American Bar Endowment | Chicago | $25,000 | 32 | $23.0M |
| Families of Spinal Muscular Atrophy | Schaumburg | $41,932 | 32 | $8.0M |
| American Bar Association Fund for Justice and Education | Chicago | $77,123 | 32 | $20.0M |
| American Society for Surgery of the Hand | Chicago | $35,000 | 31 | $7.8M |
| Illinois Association of Court Appointed | Chicago | $99,378 | 31 | $20.3M |
| Public Health Institute of Metropolitan | Chicago | $45,299 | 31 | $6.1M |
| Orthopaedic Research and Education | Rosemont | $44,689 | 31 | $5.2M |
| Blue Cross Blue Shield Association | Chicago | $43,500 | 30 | $3.2M |
| Healthcare Foundation of | Highland Park | $40,000 | 30 | $7.5M |
| Agudath Israel of Illinois | Chicago | $75,000 | 30 | $4.4M |
| Pert Foundation | Chicago | $25,000 | 30 | $327.6M |
| American Society of Anesthesiologists | Schaumburg | $25,000 | 29 | $11.1M |
| Covenant Ministries of Benevolence | Chicago | $44,250 | 29 | $2.9M |
| Foundation for Women's Cancer | Chicago | $50,000 | 28 | $2.5M |
| Osf Healthcare System | Peoria | $44,535 | 27 | $19.4M |
| Illinois Association of Community Action | Springfield | $87,968 | 27 | $12.9M |
| The Society for the Preservation | Champaign | $29,067 | 27 | $2.9M |
| Illinois Stewardship Alliance | Springfield | $26,900 | 27 | $1.7M |
| American College of Chest Physicians | Glenview | $31,200 | 26 | $1.4M |
| The Carle Foundation Hospital | Urbana | $50,000 | 26 | $4.8M |
| Alianza Americas | Chicago | $43,325 | 25 | $4.9M |
| Council of Medical Specialty Societies | Chicago | $50,000 | 25 | $12.9M |
| Pci Foundation | Chicago | $57,067 | 24 | $1.5M |
| Prevent Child Abuse America | Chicago | $40,000 | 23 | $2.1M |
| Leonard and Diane Sherman Family | Chicago | $31,400 | 23 | $4.8M |
| North Shore Exchange Nfp | Glencoe | $30,000 | 23 | $1.6M |
| Pediatric Orthopaedic Society of | Oakbrook Terrace | $30,000 | 23 | $1.0M |
| Faith and Learning International Nfp | Wheaton | $25,950 | 22 | $1.2M |
| Chicago Food Policy Action Council | Chicago | $42,000 | 22 | $3.4M |
| Carole Robertson Center for Learning | Chicago | $60,504 | 22 | $17.6M |
| Alliance to End Homelessness in | Hillside | $61,011 | 21 | $5.2M |
| Kehillah Jewish Education Fund | Skokie | $31,218 | 21 | $4.8M |
| Institute of Food Technologists | Chicago | $25,000 | 21 | $1.1M |
| National Safety Council | Itasca | $78,984 | 21 | $2.5M |
| Sigma Alpha Epsilon Foundation | Evanston | $65,097 | 21 | $4.6M |
| First Look for Charity Foundation | Oakbrook Terrace | $97,840 | 20 | $6.3M |
| Precastprestressed Concrete Institute | Chicago | $50,000 | 20 | $1.7M |
| Peoria Hospitals Mobile Medical Services | Peoria | $25,000 | 20 | $2.9M |