| Boston Foundation Inc | Boston | $25,000 | 3,613 | $906.4M |
| Combined Jewish Philanthropies of Greater Boston Inc | Boston | $25,500 | 1,772 | $1.1B |
| United Way of Massachusetts Bay Inc | Boston | $33,428 | 761 | $162.9M |
| Community Foundation of Western | Springfield | $25,000 | 686 | $83.0M |
| President and Fellows of Harvard College | Cambridge | $98,371 | 583 | $901.9M |
| Proteus Fund Inc | Waltham | $30,000 | 575 | $90.8M |
| Health Resources in Action Inc | Boston | $66,667 | 486 | $89.2M |
| All Hands on Deck Network Inc | Northampton | $40,000 | 450 | $57.5M |
| Jobs for the Future Inc | Boston | $40,000 | 432 | $52.1M |
| Jsi Research & Training Institute Inc | Boston | $43,125 | 396 | $184.4M |
| Nellie Mae Education Foundation Inc | Quincy | $25,000 | 378 | $70.0M |
| POINT32HEALTH Foundation Inc | Canton | $35,000 | 352 | $32.0M |
| Mass General Brigham Incorporated & | Somerville | $50,000 | 322 | $7.7B |
| The Harold Grinspoon Foundation | Agawam | $29,422 | 309 | $71.0M |
| Community Catalyst Inc | Boston | $81,500 | 289 | $59.8M |
| Trustees of Tufts College | Medford | $63,422 | 279 | $148.0M |
| Massachusetts Institute of Technology | Cambridge | $28,394 | 273 | $55.1M |
| National Collegiate Inventors & | Hadley | $25,000 | 273 | $46.5M |
| Northeastern University | Boston | $84,179 | 266 | $201.1M |
| Third Sector New England Inc | Boston | $52,750 | 209 | $49.5M |
| Boston Medical Center Corporation | Boston | $74,303 | 182 | $105.4M |
| Children's Hospital Corporation | Boston | $52,663 | 174 | $62.5M |
| Education Development Center Inc | Waltham | $73,865 | 167 | $66.4M |
| Boston After School & Beyond Inc | Boston | $30,848 | 157 | $22.2M |
| Mass General Brigham Incorporated | Somerville | $25,000 | 156 | $452.5M |
| Life Science Cares Inc | Cambridge | $45,000 | 149 | $17.2M |
| The Food Bank of Western | Chicopee | $72,719 | 119 | $89.1M |
| Wellington Management Foundation | Boston | $65,000 | 114 | $31.5M |
| Van Otterloo Family Foundation | Marblehead | $25,000 | 114 | $10.0M |
| Youthbuild Global Inc | Roxbury | $82,170 | 112 | $36.0M |
| Worcester Polytechnic Institute | Worcester | $71,726 | 106 | $42.8M |
| Brandeis University | Waltham | $46,837 | 96 | $26.5M |
| Catholic Schools Foundation Inc | Boston | $88,000 | 90 | $75.2M |
| Massachusetts Bar Foundation Inc | Boston | $30,000 | 88 | $15.0M |
| Bain Capital Children's Charity Ltd | Boston | $25,000 | 87 | $6.1M |
| Metro North Regional Employment Board | Malden | $50,000 | 77 | $41.3M |
| Health Care for All Inc | Boston | $45,000 | 70 | $9.7M |
| Boston Celtics Shamrock Foundation Inc | Boston | $25,000 | 67 | $6.5M |
| Partners in Health a Nonprofit Corporation | Boston | $91,675 | 64 | $38.6M |
| The Health Foundation of Central Massach | Worcester | $90,000 | 61 | $11.4M |
| Bowdoin Apartments Corporation | Malden | $25,000 | 60 | $2.4M |
| Solidago Foundation | Northampton | $25,000 | 60 | $4.6M |
| Rize Massachusetts Foundation Inc | Boston | $26,000 | 60 | $9.9M |
| Golf Fights Cancer Inc | Norton | $50,000 | 52 | $7.3M |
| Institute for Healthcare Improvement | Boston | $80,803 | 52 | $24.0M |
| The Housing Partnership Network Inc | Boston | $35,448 | 51 | $9.6M |
| The Mass Mentoring Partnership Inc | Boston | $25,810 | 51 | $5.2M |
| Bellwether Education Partners Inc | Boston | $60,000 | 51 | $6.9M |
| Trustees of Boston College | Chestnut Hill | $63,364 | 49 | $7.7M |
| Marine Biological Laboratory | Woods Hole | $61,666 | 43 | $12.5M |
| Jumpstart for Young Children Inc | Boston | $90,285 | 42 | $19.8M |
| Masschallenge Inc | Boston | $25,000 | 42 | $1.8M |
| Woodwell Climate Research Center Inc | Falmouth | $48,505 | 41 | $14.6M |
| Grassroots International Inc | Boston | $30,000 | 40 | $7.4M |
| Masshire Hampden County Workforce Board | Springfield | $58,893 | 39 | $40.7M |
| Joslin Diabetes Center Inc | Charlestown | $79,144 | 38 | $57.5M |
| Women's Foundation of Massachusetts Inc | Boston | $55,000 | 38 | $7.9M |
| Berkshire United Way Inc | Pittsfield | $30,000 | 36 | $4.1M |
| Mystic River Watershed | Arlington | $31,610 | 36 | $2.9M |
| Charlesview Charities Inc | Brighton | $27,801 | 32 | $1.5M |
| Lahey Clinic Hospital Inc | Charlestown | $28,106 | 30 | $118.6M |
| The Philanthropy Connection Inc | Cambridge | $25,000 | 30 | $1.0M |
| The National Mentoring Partnership Inc | Boston | $25,796 | 29 | $5.1M |
| Center for Community Recovery | Boston | $28,562 | 27 | $2.3M |
| Massdevelopment Hefa Trust | Boston | $50,000 | 27 | $1.8M |
| Exeter Hospital Inc | Charlestown | $46,250 | 27 | $4.5M |
| Cfleads | Accord | $50,000 | 27 | $2.6M |
| Trustees of Clark University | Worcester | $37,795 | 26 | $4.2M |
| Fraxa Research Foundation Inc | Newburyport | $50,000 | 26 | $2.5M |
| Baystate Medical Center Inc | Springfield | $30,000 | 25 | $47.8M |
| North Atlantic States Regional Council | Boston | $25,000 | 25 | $2.0M |
| National Organization for Rare | Norwell | $25,000 | 25 | $957K |
| Health Leads Inc | Boston | $28,367 | 25 | $2.5M |
| The Massachusetts Association for | Boston | $53,074 | 24 | $10.5M |
| Anticoagulation Forum Inc | Newton Highlands | $36,000 | 23 | $2.2M |
| Amherst College Trustees | Amherst | $45,000 | 23 | $3.5M |
| Cromwell Harbor Supporting Foundation | Boston | $25,000 | 23 | $4.5M |
| Ibis Reproductive Health Inc | Cambridge | $55,000 | 22 | $3.9M |
| 350ORG | Boston | $25,000 | 22 | $1.4M |
| Funders Together to End Homelessnes | Boston | $67,000 | 22 | $1.5M |
| International Union of Operating Eng | Southwick | $29,981 | 21 | $1.6M |
| Sylvania Employees Association | Peabody | $25,000 | 21 | $755K |
| Mv Vision Fellowship Fund | Vineyard Haven | $32,500 | 21 | $1.4M |
| The Technical Assistance | Boston | $81,656 | 21 | $3.7M |
| See Forward Fund Inc | Northampton | $40,000 | 20 | $1.7M |
| Prime Coalition Inc | Cambridge | $28,023 | 20 | $2.0M |